Saturday, February 14, 2015

vCSF biomarkers are associated with worst neurological outcome: Systematic review of the literature.

Results of the systematic review of the literature
Data bases: Ovid, PubMed.
Mesh terms: "Cerebrospinal Fluid Proteins AND Brain Injuries”.
Dates: Up to January 2015.

For traumatic brain injury (TBI):
1. Increase transmitter amino acid concentration in human ventricular CSF after brain trauma. Palmer et al. Neuro report 1994.
2. Traumatic Brain Injury Increases β-Amyloid Peptide 1—42 in Cerebrospinal Fluid. Raby et al. Journal of neurochemistry 1998.
3. C -tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome . Zemlan et al. Brain Research 2002.
4. Cerebrospinal Fluid Apolipoprotein E Concentration Decreases after Traumatic Brain Injury. Kay et al. Journal of neurotrauma 2003
5. Amyloid beta 1-42 and tau in cerebrospinal fluid after severe traumatic brain injury. Franz et al. Neurology 2003.
6. Spectrin breakdown products in the cerebrospinal fluid in severe head injury – preliminary observations. Farkas et al. Acta Neurochir (Wien) 2005.
7. Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury. M. Ost et al. Neurology 2006.
8. Detection of [alpha]ll-spectrin and breakdown products in humans after severe traumatic brain injury. Cardali et al. Journal of Neurosurgical Sciences 2006.
9. Clinical Significance of  II-Spectrin Breakdown Products in Cerebrospinal Fluid after Severe Traumatic Brain Injury. Pineda et al. Journal of neurotrauma 2007.
10. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Papa et al. Critical care medicine 2010.

For subarachnoid hemorrhage
1.  Decreased Cerebrospinal Fluid Apolipoprotein E After Subarachnoid Hemorrhage. Kay et al. Stroke 2003.
2. Increased levels of F2-isoprostanes following aneurysmal subarachnoid hemorrhage in humans. Lin et al. Free Radical Biology & Medicine. 2006
3. Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury. Lewis et al. Journal of neurosurgery 2007.
4. Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. Jung et al. Journal of neurosurgery 2007.
5. Prognostic value of biochemical markers of brain damage and oxidative stress in post-surgical aneurysmal subarachnoid hemorrhage patients.  Kaneda et al. Brain Research Bulletin 81. 2010
6. Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients. Li et al. Journal of Clinical Neuroscience 2014.

For acute ischemic stroke
1. Brain and Plasma Proteins in Spinal Fluid as Markers for Brain Damage and Severity of Stroke. Strand et al. Stroke 1984.
2. Determination of S-100 and Glial Fibrillary Acidic Protein Concentrations in Cerebrospinal Fluid After Brain Infarction. Aurell et al. Stroke 1991.
3. The increase of neuron-specific enolase in cerebrospinal fluid and plasma as a marker of neuronal damage in patients with acute brain infarction . Selakovic et al. Journal of clinical neuroscience 2005.
4. Dimethylarginine Levels in Cerebrospinal Fluid of Hyperacute Ischemic Stroke Patients are Associated with Stroke Severity. Brouns et al. Neurochemical research 2009.
5. Neurobiochemical Markers of Brain Damage in Cerebrospinal Fluid of Acute Ischemic Stroke Patients. Brouns et al. Clinical Chemistrys 2010.



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